ARDS was more severe in patients with COVID-19 than in those with sepsis (PaO 2/FiO 2 99 vs. Results: Forty-nine ICU patients were included (30 with COVID-19 ARDS and 19 with bacterial sepsis). RBC shape and deformability were also assessed on days 3 and 7 in COVID-19 patients. Scanning electronic microscopy was performed on RBCs from COVID-19 patients. A higher elongation index indicates greater RBC deformability. RBC deformability was determined using ektacytometry by the elongation index in relation to the shear stress (0.3 to 50 Pa) applied to the RBC membrane. A null value represents a perfect spherical shape. Methods: In this prospective, non-interventional study, shape was assessed on admission (or inclusion for the volunteers) using Pearson’s second coefficient of dissymmetry (PCD) on the histogram obtained with a flow cytometer technique. Red blood cells (RBCs), the key cells for oxygen transport, and notably their rheology, are altered during bacterial sepsis, but few data are available in patients with COVID-19. Several studies have reported that the microcirculation responds adequately to hypoxia in COVID-19 patients by increasing oxygen availability, in contrast to the inadequate response observed in patients with bacterial sepsis. 4IBMM, Center for Microscopy and Molecular Imaging, Université Libre de Bruxelles, Charleroi, Belgiumīackground: Acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-19) is associated with high mortality.3Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles, Charleroi, Belgium.2Experimental Medicine Laboratory, CHU-Charleroi Vésale, ULB 222 Unit, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.1Intensive Care, CHU-Charleroi Marie-Curie, Université Libre de Bruxelles, Charleroi, Belgium.
Michaël Piagnerelli 1,2 *, Julie Vanderelst 1, Alexandre Rousseau 2, Daniel Monteyne 3,4, David Perez-Morga 3,4, Patrick Biston 1 and Karim Zouaoui Boudjeltia 2
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